| 发明名称 |
COUPLING ENDONUCLEASES WITH END-PROCESSING ENZYMES DRIVES HIGH EFFICIENCY GENE DISRUPTION |
| 摘要 |
The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage. |
| 申请公布号 |
US2014227244(A1) |
申请公布日期 |
2014.08.14 |
| 申请号 |
US201414173705 |
申请日期 |
2014.02.05 |
| 申请人 |
Seattle Children's Research Institute |
发明人 |
Scharenberg Andrew M.;Certo Michael T.;Gwiazda Kamila Sabina |
| 分类号 |
C12N9/22 |
主分类号 |
C12N9/22 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method of increasing the mutagenic activity of an endonuclease comprising: providing the endonuclease concurrently with an end-processing enzyme. |
| 地址 |
Seattle WA US |
