发明名称 POLYNUCLEOTIDE, POLYPEPTIDE, ANIMAL MODEL AND METHOD FOR THE DEVELOPMENT OF COMPLEMENT SYSTEM MODULATORS
摘要 The present invention is in the field of molecular biology, more particularly, the present invention relates to nucleic acid sequences and amino acid sequences of a hamster C5aR1 and the use of hamster as an animal model for the characterization of complement system modulators within drug discovery.
申请公布号 US2014230081(A1) 申请公布日期 2014.08.14
申请号 US201214237880 申请日期 2012.08.06
申请人 Golz Stefan;Geerts Andreas;Köllnberger Maria 发明人 Golz Stefan;Geerts Andreas;Köllnberger Maria
分类号 C07K14/705;G01N33/50;G01N33/566 主分类号 C07K14/705
代理机构 代理人
主权项 1. A C5aR1 polynucleotide, selected from a group consisting of (i) nucleic acid molecules encoding a polypeptide comprising the amino acid sequence of SEQ ID NO: 2, (ii) nucleic acid molecules comprising the sequence of SEQ ID NO: 1, (iii) nucleic acid molecules having the sequence of SEQ ID NO: 1, (iv) nucleic acid molecules the complementary strand of which hybridizes under stringent conditions to a nucleic acid molecule of (i), (ii), or (iii); and (v) nucleic acid molecules the sequence of which differs from the sequence of a nucleic acid molecule of (iii) due to the degeneracy of the genetic code;wherein the polypeptide encoded by said nucleic acid molecule has C5aR1 activity.
地址 Mulheim an der Ruhr DE