Methods and Diets to Protect Against Chemotoxicity and Age Related Illnesses

摘要

A method of improving longevity and/or alleviating a symptom of aging or preventing age related diseases is provided. The method includes a step in which the subject's average and type of daily protein intake, IGF-I, and IGFBP1 levels, and risk factors for overall mortality, cancer and diabetes are determined. With respect to protein consumption, the relative amounts of protein calories from animal and plant sources are determined. A periodic normal calorie or low calorie but low protein fasting mimicking diet with frequencies of every 2 weeks to 2 months is provided to the subject if the subject's average daily protein intake level and type and/or IGF-I levels, and/or IGFBP1 levels is identified as being greater or lower than a predetermined cutoff intake/level and if the subject is younger than a predetermined age. The method is also shown to alleviate symptoms of chemotoxicity.

主权项

1. A method of increasing longevity in a subject, the method comprising:
identifying if the subject's average daily protein intake level is greater than a predetermined cutoff protein intake level; determining amounts of plant-based and animal-based proteins consumed by the subject; if the subject's average daily protein level is greater than the cutoff protein intake level, providing a low protein diet to the subject if the subject is younger than a predetermined age, the low protein diet providing a percent calories from protein that is less than the predetermined cutoff protein intake level; and monitoring the subject's IGF-1 levels to determine the frequency and type of diet.