Vesicle Compositions

摘要

Vesicle compositions are provided that comprise a therapeutic compound. The vesicle compositions may be capable of releasing the therapeutic compound in response to the presence of an external trigger. The vesicle compositions may comprise a plurality of biocompatible vesicles. The biocompatible vesicles may comprise a therapeutic compound for treatment of a patient in need thereof, and one or more cross-linkages between two or more of the biocompatible vesicles, each cross-linkage comprising a chemical sensing moiety and a sensed moiety. In some embodiments, the therapeutic compound may be any compound that provides palliative, curative, or otherwise beneficial effects to a patent.

主权项

1. A vesicle composition, comprising:
a first liposome, comprising: a first phospholipid; cholesterol; and a phospholipid-polyethylene glycol-boronic acid derivative conjugate; a second liposome, comprising: a second phospholipid; cholesterol; and a phospholipid-polyethylene glycol-glycosyl conjugate, at least one of the first liposome or the second liposome respectively encapsulating a first therapeutic compound or a second therapeutic compound; and the phospholipid-polyethylene glycol-boronic acid derivative conjugate of the first liposome and the phospholipid-polyethylene glycol-glycosyl conjugate of the second liposome together being configured to form at least one reversible boronic-glycosyl crosslink between the first liposome and the second liposome, provided that when: a glycosyl moiety of the phospholipid-polyethylene glycol-glycosyl conjugate comprises a glucosyl moiety, a galactosyl moiety, or a mannopyranosidyl moiety; the first liposome encapsulates the first therapeutic compound; the second liposome encapsulates the second therapeutic compound; and the first liposome is coupled to the second liposome by the at least one reversible boronic-glycosyl crosslink, the phospholipid-polyethylene glycol-boronic acid derivative conjugate is not represented bywherein n=30-60.