| 摘要 |
Novel methods for the medical treatment and/or inhibition of the development of osteoporosis, breast cancer, hypercholesterolemia, hyperlipidemia or atherosclerosis in susceptible warm-blooded animals including humans involving administration of selective estrogen receptor modulator particularly compounds having general structure (I) and an amount of a sex steroid precursor selected from the group consisting of dehydroepiandrosterone, dehydroepiandrosterone sulfate, androst-5-ene,3 , 17 48-diol and compounds converted in vivo to one of the foregoing precursor. Further administration of bisphosphonates in combination with selective estrogen receptor modulators and/or sex steroid precursor is disclosed for the medical treatment and/or inhibition of the development of osteoporosis. Pharmaceutical compositions for delivery of active ingredient(s) and kit(s) useful to the invention are also disclosed. EM-652 CANCER MAMMARY GLANID MAMMARY GLAND VAGINAL EPITHELIUM CHOLESTEROL NO EFFECT /I. ON ENDOMETRIUM BONE FORMATION ENDOMETRIUM INSULIN BONELOSSGLUCOSE BONELOSSMUSCLE MASS |
