PROGNOSTIC METHODS AND COMPOSITIONS FOR PREDICTING INTERFERON TREATMENT EFICACY IN A SUBJECT

摘要

The present invention relates to methods, compositions and kits for predicting, assessing and evaluating responsiveness and success of interferon treatment as well as methods for monitoring disease progression and pathophysiology in a subject treated with interferon, using miR-146a and optionally at least one of miR-146a regulated genes as biomarkers.

主权项

1. A prognostic method for predicting, assessing and monitoring responsiveness of a mammalian subject to interferon treatment, said method comprising the steps of:
(a) determining the level of expression of miR-146a and optionally of at least one of miR-146a regulated genes in a biological sample of said subject to obtain an expression value; (b) comparing the expression value obtained in step (a) to a predetermined standard expression value or to an expression value of miR146a and optionally of at least one of miR-146a regulated genes in at least one control sample; thereby predicting, assessing and monitoring responsiveness of a mammalian subject to interferon treatment