| 发明名称 |
STRESS TOLERANT BIFIDOBACTERIA |
| 摘要 |
The present invention relates in general to the field of Bifidobacteria. In particular, the present invention relates to the field of Bifidobacteria with a modulated stress resistance. One embodiment of the present invention is a Bifidobacterium with a constitutively modulated DnaK, GrpE and/or CIpB expression. |
| 申请公布号 |
US2014227789(A1) |
申请公布日期 |
2014.08.14 |
| 申请号 |
US201414258758 |
申请日期 |
2014.04.22 |
| 申请人 |
NESTEC S.A. |
发明人 |
Berger Bernard;Rezzonico Ernea;Arigoni Fabrizio |
| 分类号 |
C12N15/87 |
主分类号 |
C12N15/87 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method to increase the stress resistance of a Bifidobacterium comprising the step of constitutively upregulating an expression of a gene selected from the group consisting of DnaK, DnaJ, GrpE, C1pB and combinations thereof, by introducing at least one point mutation in the hspR gene of the Bifidobacterium so that a characteristic selected from the group consisting of HspR expression, HspR functioning and a combination thereof is hindered. |
| 地址 |
Vevey CH |
