CROSS-LINKED HYALURONIC ACID AND COLLAGEN AND USES THEREOF

摘要

The present invention discloses a cross-linked hyaluronic acid/collagen formulation which has improved composition for dermal filling and higher persistence than cross-linked collagen or HA alone. Also disclosed are methods for preparing cross-linked hyaluronic acid/collagen formulations and using such for augmenting soft tissues in mammals.

主权项

1. A process for preparing an injectable composition useful for correcting mammary hypoplasia, the process comprising:
(1) contacting hyaluronic acid (HA) with a cross-linker to allow cross-linking of the HA by the cross-linker, thereby forming a first composition comprising a crosslinked HA; (2) contacting the crosslinked HA with collagen to form a second composition comprising a collagen layer crosslinked to and surrounding a crosslinked HA core; (3) homogenizing the second composition to form an injectable composition, the composition being injectable under normal manual pressure though a 25 gauge needle, thereby preparing the injectable composition useful for correcting the mammary hypoplasia.