Tissue Engineering Methods and Compositions

摘要

Cells are employed in conjunction with unique biologically-compatible scaffold structures to generate differentiated tissues and structures, both in vitro and in vivo. The presently disclosed subject matter further relates to methods of forming and using improved tissue engineered scaffolds that can be used as substrates to facilitate the growth and differentiation of cells.

主权项

1. A composition for use in the treatment of a tissue pathology in a subject, the composition comprising:
(a) an adipose-derived stem (ADS) cell and an effective amount of a biologically active agent, in which the biologically activate agent is a BMP-6 polypeptide or a functional fragment thereof; and (b) a pharmaceutically acceptable carrier or excipient, wherein the treatment comprises exposing the ADS cell to an effective amount of said biologically active agent sufficient to induce the ADS cell to differentiate into a cell capable of treating the tissue pathology in the subject upon administration of the composition to the subject.