| 发明名称 |
USE OF AN IL12 RECEPTOR-BETA 1 SPLICE VARIANT TO DIAGNOSE ACTIVE TUBERCULOSIS |
| 摘要 |
The present invention describes compositions for both diagnostic and therapeutic applications. In one embodiment, the present invention contemplates a method of identifying an active M. tuberculosis infection. In another embodiment, the present invention contemplates a method of monitoring a M. tuberculosis infection. In yet another embodiment, the present invention contemplates a method of monitoring a patient's response to treatment for an active M. tuberculosis infection. In a further embodiment, the present invention contemplates a method of monitoring a patient's response to treatment for an active M. tuberculosis infection. |
| 申请公布号 |
US2014227324(A1) |
申请公布日期 |
2014.08.14 |
| 申请号 |
US201313764289 |
申请日期 |
2013.02.11 |
| 申请人 |
Robinson Richard T.;Cooper Andrea M. |
发明人 |
Robinson Richard T.;Cooper Andrea M. |
| 分类号 |
A61K39/04;C12Q1/68 |
主分类号 |
A61K39/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of identifying an active M. tuberculosis infection, comprising:
a) providing a patient infected with M. tuberculosis, b) determining the amount of IL12Rβ1 isoform 1 mRNA and IL12Rβ1 isoform 2 mRNA in a cell from said patient, wherein said cell is a peripheral blood mononuclear cell, c) diagnosing the patient as having an active M. tuberculosis infection if the amount of IL12Rβ1 isoform 2 mRNA is greater than the amount of IL12Rβ1 isoform 1 mRNA, d) initiating a therapeutic treatment on said patient with an active M. tuberculosis infection. |
| 地址 |
Milwaukee WI US |
