Engineered Type IV Pilin of Clostridium difficile

摘要

The present invention relates to engineered Clostridium difficile type IV pilin (tfp) genes, type IV pilin proteins which can serve as a diagnostic marker for identification of patients infected with C. difficile, and vaccines comprising type IV pilin proteins, antigenic fragments and variants thereof for therapeutic interventions.

主权项

1. A pharmaceutical composition for inducing an immune response against Clostridium difficile comprising an isolated C. difficile type IV pilin or an antigenic fragment or variant thereof, wherein the variant is recognized by an antibody that binds the C. difficile type IV pilin.