| 摘要 |
The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neturodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries. |
| 主权项 |
1. A thiazole according to Formula (I), wherein R1 is a moiety of the formula —NR5R6; R2, R3 and R5 are selected independently from H, C1-C6-alkyl, C2-C6-alkenyl and C2-C6-alkynyl; R4 is selected from the group consisting of H, C1-C6-alkyl, C2-C6-alkenyl and C2-C6-alkynyl and NR8R9 wherein R8 and R9 are independently selected from the group consisting of H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkyl alkoxy carbonyl and C1-C6-alkyl acyloxy; R6 is selected from the group consisting of C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkyl alkoxy, aryl, heteroaryl, C3-C8-cycloalkyl, C3-C8-heterocycloalkyl, C1-C6-alkyl aryl, C1-C6-alkyl heteroaryl, C1-C6-alkyl C3-C8-cycloalkyl, C1-C6-alkyl C3-C8-heterocycloalkyl, C1-C6-alkyl acyl, C1-C6-alkyl carboxy, C1-C6-alkyl amino, C1-C6-alkyl aminocarbonyl, C1-C6-alkyl alkoxycarbonyl and C1-C6-alkyl acyl amino; or R5 and R6, together with the carbon atoms they are linked to, form a 5-8-membered saturated or aromatic ring containing optionally one or more heteroatoms selected from the group consisting of O, N and S; and X is O; as well as isomers thereof said thiazole being suitable as active ingredient in a medicament. |
