| 摘要 |
The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I,;;and the variables R1 and R2 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. |
| 主权项 |
1. A compound of Formula Iwherein
R1 is hydrogen or methyl, wherein said methyl is optionally substituted with one to three fluoro; R2 is a 5- to 10-membered heteroaryl, having one to four heteroatoms independently selected from N, O or S, wherein at least one of the heteroatoms is N and wherein said N is optionally substituted with R4; and wherein said 5- to 10-membered heteroaryl is optionally substituted on carbon with one to three R3; R3 at each occurrence is independently selected from the group consisting of halogen, hydroxy, cyano, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C3-6Cycloalkoxy, C3-6cycloalkoxy-(CR5aR5b)m—, C3-6cycloalkyl-(CR5aR5b)n—O—, —(CR5aR5b)m—C3-6cycloalkyl or —(CR5aR5b)m-(4- to 6-membered heterocycloalkyl); wherein said C1-6alkyl, C1-6alkoxy or C1-6alkoxy-C1-6alkyl are each optionally substituted with one to three fluoro and wherein said C3-6cycloalkyl, C3-6cycloalkoxy and (4- to 6-membered heterocycloalkyl) moieties are optionally substituted with one to three substituents independently selected from the group consisting of fluoro, methyl, fluoromethyl, difluoromethyl or trifluoromethyl; R4 is hydrogen, C1-6alkyl, —(CR5aR5b)m—C3-6cycloalkyl or —(CR5aR5b)m-(4- to 6-membered heterocycloalkyl); wherein said C1-6alkyl, C3-6cycloalkyl and -(4- to 6-membered heterocycloalkyl) moieties are each optionally substituted with one to three substituents independently selected from fluoro, methyl, trifluoromethyl, methoxy or trifluoromethoxy; R5a and R5b are independently hydrogen, methyl, fluoromethyl, difluoromethyl, trifluoromethyl or methoxy; m at each occurrence is independently 0, 1 or 2; and n is 1, 2 or 3;or a tautomer thereof or a pharmaceutically acceptable salt of said compound or tautomer. |
