| 发明名称 |
FENTANYL DERIVATIVES AS PH-DEPENDENT OPIOID RECEPTOR AGONISTS |
| 摘要 |
The invention relates to fluorinated fentanyl derivatives that function as opioid receptor agonists, which activate target opioid receptors in a pH-dependent manner, and are thus selective for the receptors in inflamed (acidic) milieu; uses thereof and pharmaceutical compositions comprising them. |
| 申请公布号 |
US2014228406(A1) |
申请公布日期 |
2014.08.14 |
| 申请号 |
US201214239461 |
申请日期 |
2012.08.17 |
| 申请人 |
Stein Christoph;Weber Marcus;Zöllner Christian;Scharkoi Olga |
发明人 |
Stein Christoph;Weber Marcus;Zöllner Christian;Scharkoi Olga |
| 分类号 |
C07D211/58 |
主分类号 |
C07D211/58 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. Compound of the general Formula I whereby at least one of R1, R2, R3, R4 is F, and the remaining residues at positions R1, R2, R3, R4 are H. |
| 地址 |
Berlin DE |
