发明名称 |
SKIN PERMEATING AND CELL ENTERING (SPACE) PEPTIDES AND METHODS OF USE THEREFOR |
摘要 |
Compositions that facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (SC) and/or the cellular membranes of viable cells are provided. In some embodiments, the compositions include a peptide, an active agent, and a carrier that includes the active agent, wherein the peptide has an amino acid sequence set forth in any of SEQ ID NOs: 1-18; the peptide is associated with and/or conjugated to the active agent, the carrier, or both; the carrier is selected from the group consisting of a micelle, a liposome, an ethosome, and combinations thereof; and the composition is capable of penetrating a stratum corneum (SC) layer when contacted therewith or penetrating a cell when contacted therewith, and optionally wherein the composition further includes one or more free peptides having an amino acid sequence set forth in any of SEQ ID NOs: 1-18. Also provided are methods for delivering active agents to subjects, methods for treating subjects having dermatological diseases, and methods for attenuating expression of mRNAs of subjects in need thereof and/or for treating diseases and/or disorders thereby. |
申请公布号 |
US2014227174(A1) |
申请公布日期 |
2014.08.14 |
申请号 |
US201313764359 |
申请日期 |
2013.02.11 |
申请人 |
CONVOY THERAPEUTICS ;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
Muraski John A.;Mitragotri Samir;Chen Ming |
分类号 |
A61K47/42;A61K31/728;A61K38/13;A61K47/48;A61K31/7088 |
主分类号 |
A61K47/42 |
代理机构 |
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代理人 |
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主权项 |
1. A composition comprising a peptide, an active agent, and a carrier comprising the active agent, wherein:
(a) the peptide comprises an amino acid sequence set forth in any of SEQ ID NOs: 1-18; (b) the peptide is associated with and/or conjugated to the active agent, the carrier, or both; (c) the carrier is selected from the group consisting of a micelle, a liposome, an ethosome, and combinations thereof; and (d) the composition is capable of penetrating a stratum corneum (SC) layer when contacted therewith or penetrating a cell when contacted therewith,and optionally wherein the composition further comprises one or more free peptides comprising an amino acid sequence set forth in any of SEQ ID NOs: 1-18. |
地址 |
Las Vegas NV US |