发明名称 |
FIBRONECTIN TYPE III DOMAIN PROTEINS WITH ENHANCED SOLUBILITY |
摘要 |
Provided herein are polypeptides comprising a modified fibronectin type III (Fn3) domain, wherein the amino acid corresponding to residue 58 of SEQ ID NO: 1 is mutated, and wherein the solubility is enhanced relative to the solubility of a Fn3 domain in which the amino acid corresponding to residue 58 of SEQ ID NO: 1 is not mutated. Also provided are libraries comprising a plurality of the polypeptides and a method for identifying a polypeptide that binds to a target. |
申请公布号 |
WO2014124017(A1) |
申请公布日期 |
2014.08.14 |
申请号 |
WO2014US14887 |
申请日期 |
2014.02.05 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
YAMNIUK, AARON, P.;KRYSTEK, STANLEY, R. |
分类号 |
C07K14/435 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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