COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE

摘要

The present invention relates to novel combinations suitable for the treatment of dyskinesia associated with dopamine agonist therapy in Parkinson's Disease, which comprise, as active ingredients, at least one low molecular weight nicotinic acetylcholine receptor alpha 7 activator and at least one low molecular weight metabotropic glutamate receptor 5 antagonist; to their preparation; to their use as medicaments and to medicaments comprising them.

主权项

1. A combination, which comprises:
(A) at least one low molecular weight nicotinic acetylcholine receptor alpha 7 activator, selected from a nicotinic acetylcholine receptor alpha 7 agonist and a nicotinic acetylcholine receptor alpha 7 positive allosteric modulator, as the first active ingredient; and (B) at least one low molecular weight metabotropic glutamate receptor 5 antagonist as the second active ingredient; in which the active ingredients are present in each case in free form or in the form of a pharmaceutically acceptable salt; for the use as a medicament.