PROCESS FOR THE PRODUCTION OF MOXONIDINE

摘要

4,6-dichloro-2-methyl-5-(1-acyl-2-imidazolin-2-yl)-aminopyrimidine is reacted with methanol in the presence of a non-ionic organic base, and moxonidine is obtained directly from the reaction mixture.

主权项

1. A process for the synthesis of moxonidine of formula I or a pharmaceutically acceptable salt thereof, the process comprising the steps of:reacting a 4,6-dichloro-2-methyl-5-(1-acyl-2-imidazolin-2-yl)-aminopyrimidine derivative of formula II wherein R denotes an acyl group;with methanol in the presence of a non-ionic organic base; andobtaining moxonidine (I) from the reaction mixture.