| 主权项 |
1. A method for treating a disease or disorder where modulation of a kinase is implicated, wherein the method comprises administering to a system or subject in need of such treatment an effective amount of a compound of Formula (I) or Formula (II), or pharmaceutically acceptable salt thereof, wherein:
m is 1 and R20 is selected from H, halo, C1-C6alkyl, C1-C6haloalkyl, C1-C6haloalkoxy, deuterium, deuterated C1-C6alkyl, —CN, —(CR92)nOR4, —C(O)R4, —(CR92)nC(═O)OR4, R10, —(CR92)nR10, —((CR92)nO)tR4, —(CR92)nO(CR92)nR7, —(CR92)nC(═O)R4, —C(═O)N(R4)2, —OR4, and —(CR92)nCN;or m is 4 and R20 is deuterium;R1 is selected from C1-C6alkyl and halo;each R11 is independently selected from H, halo and C1-C6alkyl;L1 is a bond, —NH— or —C(O)NH—;L2 is —(CR92)n—, —CHR6—, —(CR92)nO—, —NH—, —(CR92)nC(═O)—, —C(═O)O(CR92)n—, —(CR92)nOC(═O)NR4—, —(CR92)nNR4C(═O)(CR92)n—, —(CR92)nNR4C(═O)—, or —(CR92)nNR4C(═O)O—;R2 is R3 or L2R3;R3 is selected from an unsubstituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O and S, a piperidinone, a oxazolidin-2-one, pyrrolidinone, a pyrrolidin-2-one and a substituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O and S, wherein the substituted 4-6 membered heterocycloalkyl of R3 is substituted with 1-4 substituents independently selected from C1-C6alkyl halo, —CN, C1-C6haloalkyl, —OR4, —C(═O)OR4, —C(═O)R4, —C(═O)R7, —C(═O)OR5, —(CR92)nOR4, —O(CR92)nOR4, —C(═O)O(CR92)nOR4, —N(R4)2, —C(═O)NR42, —NR4C(═O)OR4, —NR4C(═O)(CR92)nOR4, —NR4(CR92)nOR4, —NR4S(═O)2R4, —N(C(═O)OR4)2, R8, —(CR92)nR8, deuterated C1-C6alkoxy, —S(═O)2R4, —S(═O)2R7, —S(═O)2R8, —S(═O)2N(R4)2, —S(═O)2NHC(═O)OR4, —S(═O)2(CR92)nC(═O)OR4, S(═O)2(CR92)nOR4, a Spiro attached dioxolane, a spiro attached dioxolane which is substituted with C1-C6alkyl, a spiro attached dioxane, a spiro attached tetrahydrofuranly, a spiro attached oxetane, a spiro attached cyclobutanone, a spiro attached cyclobutanol, a C1 alkyl bridge, an unsubstituted 5-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O and S and a 5-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O and S substituted with 1-3 substituents independently selected from C1-C6alkyl, halo, C1-C6haloalkyl, C1-C6haloalkoxy, —OR4 and R8;each R4 is independently selected from H and C1-C6alkyl;R5 is an unsubstituted C3-C8cycloalkyl, an unsubstituted 5-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N or O or a C3-C8cycloalkyl substituted with 1-3 substituents independently selected from C1-C6alkyl;each R6 is independently selected from —NR4C(O)OR4, —OR4 and —(CR92)nOR4;each R7 is independently selected from C1-C6haloalkyl;R8 is selected from an unsubstituted phenyl, unsubstituted 5-6 membered heteroaryl with 1-3 heteroatoms independently selected from N, O and S, an unsubstituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, an unsubstituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O and S, an unsubstituted C3-C8cycloalkyl, a substituted 5-6 membered heteroaryl with 1-3 heteroatoms independently selected from N, O and S, a substituted phenyl, a substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, a substituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O and S, a substituted C3-C8cycloalkyl, a tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one, a oxazolidin-2-one, pyrrolidinone and a pyrrolidin-2-one,
wherein the substituted phenyl, the substituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O and S, the substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, substituted C3-C8cycloalkyl and substituted 4-6 membered heterocycloalkyl of R8 are substituted with 1-3 substituents independently selected from C1-C6alkyl, —(C(R9)2)nOR4, —(C(R9)2)nR5, —(C(R9)2)nC(O)OR4, —C(O)OR4 and —S(O)2R4;each R9 is independently selected from H and C1-C6alkyl;R10 is selected from an unsubstituted phenyl, unsubstituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O and S, an unsubstituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, an unsubstituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O and S, an unsubstituted C3-C8cycloalkyl, a substituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O and S, a substituted phenyl, a substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, a substituted 4-6 membered heterocycloalkyl with 1-2 heteroatoms independently selected from N, O and S, a substituted C3-C8cycloalkyl, a oxazolidin-2-one, pyrrolidinone and a pyrrolidin-2-one,
wherein the substituted phenyl, the substituted 5-6 membered heteroaryl with 1-2 heteroatoms independently selected from N, O and S, the substituted 5 membered heteroaryl with 1-4 heteroatoms selected from N, substituted C3-C8cycloalkyl and substituted 4-6 membered heterocycloalkyl of R8 are substituted with 1-3 substituents independently selected from C1-C6alkyl [Me], —(C(R9)2)nOR4, —(C(R9)2)nR5, —(C(R9)2)nC(O)OR4 and —S(O)2R4;t is 1, 2 or 3, andeach n is independently selected from 1, 2, 3 and 4; wherein the kinase is selected from c-kit, PDGFRα and PDGFRβ, and wherein the disease is selected from asthma, allergic rhinitis, allergic sinusitis and Crohn's disease. |
