发明名称 FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS
摘要 The present invention provides a compound which has the effect of PDE inhibition, and which is useful as an agent for preventing or treating schizophrenia or so on represented by the formula (I):
申请公布号 US2014228320(A1) 申请公布日期 2014.08.14
申请号 US201414253139 申请日期 2014.04.15
申请人 Takeda Pharmaceutical Company Limited 发明人 TANIGUCHI Takahiko;YOSHIKAWA Masato;MIURA Kasei;HASUI Tomoaki;HONDA Eiji;IMAMURA Keisuke;KAMATA Makoto;KAMISAKI Haruhi;QUINN John F.;RAKER Joseph;CAMARA Fatoumata;WANG Yi
分类号 C07D471/04;C07D471/14;C07D487/04;C07D498/04;C07F7/10 主分类号 C07D471/04
代理机构 代理人
主权项 1. A compound represented by the formula (I): wherein ring A represents an optionally substituted 6-membered ring, any one or two of from Z1 to Z4 represent —N═, and the others represent —CH═; Y represents an oxygen atom, a sulfur atom, an optionally substituted methylene group or —NRc—; Rc represents a hydrogen atom, or a substituent; and R represents (1) a group represented by the formula: wherein R1 represents a phenyl group or 5- to 10-membered heterocyclic group, each of which is optionally substituted; L represents a sulfur atom, an oxygen atom, an optionally substituted methylene group, —CO—, —NRa—, —CH2O—, —OCH2—, —NRaCOO—, —OCONRa—, —NRaCONRb—, —NRaCOCH2—, —CH2CONRa—, —NRaCO—, —CONRa—, Ra and Rb are the same or different and each represents a hydrogen atom, or an optionally substituted C1-6 alkyl group, or L and R1 in combination optionally form an optionally substituted bi- or tri-cyclic fused heterocyclic group; and ring B1 represents a benzene ring, a pyridine ring, a pyrimidine ring, a pyrazine ring or a pyridazine ring, each of which is optionally substituted; or (2) a group represented by the formula: wherein R2 represents a phenyl group or 5- to 10-membered heterocyclic group, each of which is optionally substituted; ring B2 represents a benzene ring, a pyridine ring, a pyrimidine ring, a pyrazine ring or a pyridazine ring, each of which is optionally substituted; and ring D represents an optionally further substituted 5- or 6-membered ring; provided that 3,3′-benzene-1,4-diylbis(1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one), 1-cyclohexyl-3-(4-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one, 3-(4-phenoxyphenyl)-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one, 3,3′-benzene-1,4-diylbis(1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one), and 3-[8-(4-methylpiperazin-1-yl)naphthalen-2-yl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one are excluded; or a salt thereof.
地址 Osaka JP