发明名称 |
METHODS FOR REDUCING AGGREGATE LEVELS IN PROTEIN PREPARATIONS BY TREATMENT WITH THIO-HETEROCYCLIC CATIONS |
摘要 |
A method of reducing the aggregate content in a protein preparation having a target protein includes contacting the protein preparation with a thio-heterocyclic cation to form a mixture, contacting the mixture with at least one functionalized solid to remove excess thio-heterocyclic cations; and optionally contacting the mixture, simultaneously or sequentially, with at least one further functionalized solid to further reduce aggregate content of the protein preparation. |
申请公布号 |
WO2014123486(A1) |
申请公布日期 |
2014.08.14 |
申请号 |
WO2014SG00048 |
申请日期 |
2014.02.05 |
申请人 |
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH |
发明人 |
GAGNON, PETER STANLEY |
分类号 |
C07K1/22;B01D15/16;C07D279/18;C07K16/00 |
主分类号 |
C07K1/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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