发明名称 CONDENSED HETEROCYCLIC COMPOUND
摘要 The present invention provides a fused heterocyclic compound having an RORγt inhibitory action. The present invention relates to a compound represented by the formula (I′):;;wherein each symbol is as defined in the specification, provided that 2-(2-((4-cyanophenyl)amino)-2-oxoethoxy)-N-(9-ethyl-9H-carbazol-3-yl)acetamide and N-(4-cyanophenyl)-N′-(9-ethyl-9H-carbazol-3-yl)-3-methylpentanediamide are excluded, or a salt thereof.
申请公布号 US2014228409(A1) 申请公布日期 2014.08.14
申请号 US201214346071 申请日期 2012.09.21
申请人 Takeda Pharmaceutical Company Limited 发明人 Yamamoto Satoshi;Shirai Junya;Fukase Yoshiyuki;Tomata Yoshihide;Sato Ayumu;Ochida Atsuko;Yonemori Kazuko;Nakagawa Hideyuki
分类号 C07D401/12;C07D209/08;C07D209/88 主分类号 C07D401/12
代理机构 代理人
主权项 1. A compound represented by the formula (I′):wherein R1A is an optionally substituted hydrocarbon group or an optionally substituted hydrocarbon-oxy group, R2A and R3A are each independently a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted hydrocarbon-oxy group, an acyl group, a halogen atom, a cyano group, an optionally substituted hydrocarbon-amino group, an optionally substituted hydrocarbon-sulfanyl group, an optionally substituted hydrocarbon-sulfenyl group, an optionally substituted hydrocarbon-sulfonyl group or a nitro group, or R2A and R3A optionally form, together with the carbon atoms which they are bonded to, an optionally substituted hydrocarbon ring, R5A is a hydrogen atom or a halogen atom, Q′ is a bivalent group selected fromwherein [A1] are the same or different and each is a methylene group optionally substituted by substituent(s) selected from a hydroxy group, a phenyl group and an optionally substituted C1-6 alkyl group, wherein the two substituents bonded to the single carbon atom are optionally combined to each other to form a hydrocarbon ring, and [A2] are the same or different and each is a methylene group optionally substituted by substituent(s) selected from a hydroxy group and an optionally substituted C1-6 alkyl group, wherein the two substituents bonded to the single carbon atom are optionally combined to each other to form a hydrocarbon ring, or the methylene group in [A1] or [A2] is optionally combined to the substituent on the adjacent methylene group to form an optionally substituted hydrocarbon ring, R4A and R4B are the same or different and each is an optionally substituted hydrocarbon group, X′ is an oxygen atom, a sulfur atom, or an imino group having an optionally substituted hydrocarbon group or a hydrogen atom, n is an integer of 1 to 5, n′ is an integer of 1 to 4, n″ is an integer of 1 to 3, and x′ and y′ are each 0 or natural number, and the sum is 0 to 4, and Ring B′ is a benzene ring optionally having additional substituent(s), or a pyridine ring optionally having additional substituent(s), provided that when R5A is a halogen atom, then Ring B′ is a benzene ring optionally having additional substituent(s), provided that 2-(2-((4-cyanophenyl)amino)-2-oxoethoxy)-N-(9-ethyl-9H-carbazol-3-yl)acetamide and N-(4-cyanophenyl)-N′-(9-ethyl-9H-carbazol-3-yl)-3-methylpentanediamide are excluded,or a salt thereof.
地址 Osaka-shi, Osaka JP
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