METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING A DISEASE RELATED TO GLYCAN DYSREGULATION

摘要

Contemplated compositions and methods are directed to prevent and/or treat various autoimmune diseases that are typically associated with glycan dysregulation, and especially autoimmune demyelinating diseases. Further especially contemplated aspects include animal models and systems for screening compounds to treat and/or prevent such diseases.

主权项

1. A method for treating insulin-dependent diabetes mellitus comprising administering to a subject having insulin-dependent diabetes mellitus a therapeutically effective amount of at least one of (a) a sugar donor for Mgat5, (b) an agonist for Mgat5, and (c) a metabolite, regulator, or an agonist of a pathway for synthesis of a sugar donor for Mgat5, wherein the level of Mgat5 modified glycans is increased in the subject, thereby treating the subject's insulin-dependent diabetes mellitus.