发明名称 |
A1 MOIETY OF CHOLERA TOXIN A SUBUNIT AS AN ADJUVANT FOR MUCOSAL AND SYSTEMIC VACCINES |
摘要 |
The present invention relates to cholera toxin CTA1 protein fragments, adjuvant compositions, and methods relating to adjuvants for vaccines. The invention also relates to using recombinant CTA1 fragments conjugated to a polypeptide containing a protein transduction domain or cell-penetrating peptide as an immunomodulator. |
申请公布号 |
US2014227312(A1) |
申请公布日期 |
2014.08.14 |
申请号 |
US200912603211 |
申请日期 |
2009.10.21 |
申请人 |
Czerkinsky Cecil;Song Manki |
发明人 |
Czerkinsky Cecil;Song Manki |
分类号 |
C12N9/10;A61K39/02;C12P21/06;C07H21/04;C07K14/425;C12N1/21;C07K14/28 |
主分类号 |
C12N9/10 |
代理机构 |
|
代理人 |
|
主权项 |
1. A fusion protein comprising an A1 subunit of a bacterial enterotoxin selected from the group consisting of cholera toxin A1 and Escherichia coli heat-labile enterotoxin A1, conjugated at the amino terminus, carboxy terminus, or both amino and carboxy terminus with a polypeptide belonging to the class of protein transduction domains or cell-penetrating peptides. |
地址 |
Seoul KR |