FILTRATION ELEMENT AND ASSEMBLY FOR BIOPROCESS APPLICATIONS

摘要

Provided are filtration devices for purifying fluids from bioprocess applications and processes for using the same. The fluid filter elements or cells and fluid filter assemblies or capsules minimize upstream and residual volumes by the use of substantially flat interior surfaces. Desired pressure ratings are also met without the use of external equipment. Such capsules and assemblies can be disposable. The cells and capsules are in particular suitable for intermediate filtration volumes (150-2500 cm2 effective filtration area (EFA)) of biopharmaceutical processes. One or more of the following features are also provided by these cells and capsules: ergonomic connections, stand alone device with desired pressure rating, offer a small footprint when running in series or parallel, ability to monitor fluid level during operation, provide various EFA sizes to allow for use with minimal fluid volumes, and offer an integral seal between clean and dirty process fluid streams.

主权项

1. A filtration capsule comprising:
a first and second shells that are sealably attached to each other, wherein both shells each comprise a curved exterior surface that extends in an arc and a substantially flat interior wall that is integral to the shell; an inlet and an outlet that are substantially parallel to the substantially flat interior walls; and one or more filter elements contained in the filtration capsule, each filter element comprising an outer surface in fluid communication with the inlet and an inner surface in fluid communication with the outlet.