发明名称 |
PROCESS FOR PRODUCING L-METHIONINE FROM O-PHOSPHO-L-HOMOSERINE AND METHANETHIOL EMPLOYING A MUTATED CYSTATHIONINE GAMMA-SYNTHASE |
摘要 |
Provided is a method for producing L-methionine in which O-phospho-L-homoserine and methanethiol are enzymatically converted into L-methionine and H3P04. Such a conversion is achieved by an enzyme called O-phospho-L-homoserine (OHPS) dependent methionine synthase. Also described are O-phospho-L-homoserine (OHPS) dependent methionine synthases, i.e. proteins which are able to enzymatically convert O-phospho-L-homoserine and methanethiol into L-methionine and H3PO4 as well as microorganisms which have been genetically modified so as to be able to produce L-methionine from O-phospho-L-homoserine and methanethiol. Furthermore described are methods to screen for enzymes that catalyse the conversion of O-phospho-L-homoserine and methanethiol into L-methionine and H3PO4. |
申请公布号 |
WO2014064244(A3) |
申请公布日期 |
2014.08.14 |
申请号 |
WO2013EP72380 |
申请日期 |
2013.10.25 |
申请人 |
ADISSEO FRANCE S.A.S. |
发明人 |
MERKAMM, MURIEL;LOUIS, DOMINIQUE;JAILLARDON, KARINE;THOMAS, DOMINIQUE;MARLIERE, PHILIPPE |
分类号 |
C12P13/12;C12N9/10;C12N15/10;C12P11/00;C12P19/40;C12P21/02 |
主分类号 |
C12P13/12 |
代理机构 |
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地址 |
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