POLOXAMINE HYDROGELS AND THE USE THEREOF FOR BONE REGENERATION OR REPAIR

摘要

The invention relates to poloxamine and cyclodextrin hydrogels that can comprise a statin. The incorporation of cyclodextrins allows the reduction of the concentration of poloxamine required for gel formation and also increases the osteogenic/osteoinductive activity of the poloxamine. Said hydrogels promote the differentiation of mesenchymal stem cells into osteoblasts and can be used for bone repair, bone regeneration or increasing bone formation.