NOVEL XANTHINE OXIDASE INHIBITOR COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF

摘要

Disclosed are a compound of formula (I) or pharmaceutically acceptable salt thereof, wherein R1 is selected from H, halogen, C1-2 alkyl, substituted C1-2 alkyl, and C1-2 alkoxy, and R1 is CH3 when ring A is pentabasic monocyclic heteroaryl; R2 is CN, I, C1, Br, -CF3, or -OCH3; R3 is H or D; ring A is thiazole, selenazole, oxazole, or pyridine; ring E is formula (A), (B), or (C); G1 is selected from O or NRa; G2, G3, and G4 are independently selected from -CRa or -CRbRc; Ra is selected from H, deuterium, halogen, C1-6 alkyl, or substituted C1-6 alkyl, and Ra does not comprise deuterium or halogen when Ra is connected to N; Rb and Rc are each independently selected from H, deuterium, halogen, C1-4 alkyl, or substituted C1-4 alkyl; and optionally Rb and Rc may cyclize to form C3-7 membered cycloalkyl or substituted C3-7 membered cycloalkyl. The compound or pharmaceutically acceptable salt thereof is used to prepare drugs for preventing or treating hyperuricemia, gout, diabetic nephropathy, inflammatory diseases, and neurological diseases.