Peptide fragmentation as an approach in modeling of an active peptide and designing a competitive inhibitory peptide for HMG-CoA reductase

摘要

PURPOSE: A peptide which suppresses HMG-CoA reductase is provided to suppress cholesterol synthesis and to treat cardiovascular diseases. CONSTITUTION: A peptide which suppresses HMG-CoA reductase contains a sequence selected from sequence numbers 1-5. A cholesterol synthesis inhibitor contains the peptide. The cholesterol synthesis inhibitor is used for treating cardiovascular diseases.