| 摘要 |
An orally inhalable formulation comprising nicotine and a propellant for use in a method of relieving or preventing nicotine craving, wherein a daily dose of inhalable formulation is provided in one or more pressurized containers, wherein the inhalable formulation is for pulmonary administration using a simulated cigarette having a housing, a reservoir configured to receive and contain a charge of inhalable formulation from the pressurized container and an outlet valve, wherein the daily dose comprises a deliverable daily dose of less than 60 mg of nicotine. A simulated cigarette system comprising an orally inhalable formulation comprising nicotine and a propellant, a pressurized refill container containing the inhalable formulation, a simulated cigarette for pulmonary administration of the inhalable formulation comprising a housing, a reservoir configured to receive and contain a charge of inhalable formulation from the pressurized container, a breathe actuated valve configured to eject the formulation as droplets, wherein at least some of the droplets have a diameter of 10 µm or less, and wherein said refill container contains 2mg to 20mg of nicotine, wherein at least 60% of the inhalable formulation is deliverable via the pulmonary route. |
