摘要 |
<p>The present invention relates to a DNA vaccine that can effectively induce immune responses specific to multiple antigens for treating chronic Hepatitis B, and to a method for preparing the DNA vaccine, wherein said DNA vaccine comprises antigenic genes encoding hepatitis B surface antigen (HBsAg), an L protein, a core, and a polymerase, and preferably further IL-12 variant as an adjuvant. The antigenic genes of said vaccine enhance the expression of antigens through codon-optimization, and effectively induce antibody responses specific to antigen used and cell-mediated immune responses. Accordingly, the DNA vaccine of the invention can be effectively used for curing chronic Hepatitis B.</p> |
申请人 |
POSTECH FOUNDATION;DONG-A PHARMACEUTICAL CO., LTD.;GENEXINE, INC.;DAEWOONG PHARMACEUTICAL CO., LTD. |
发明人 |
SUNG, YOUNG CHUL;YANG, SE HWAN;IM, SE JIN;LEE, CHANG GEUN;PARK, SU HYUNG;SONG, MAN KI;SON, JONG MOON;YOON, SEUNG KEW;KIM, CHAE YOUNG;KIM, BYUNG MOON;LEE, SUNG HEE;KIM, WON BAE |