摘要 |
PURPOSE: A porcine reproductive and respiratory syndrome virus-like antigen and an immunogenic composition containing the same are provided to express porcine reproductive and respiratory syndrome virus proteins and to produce a vaccine. CONSTITUTION: A porcine reproductive and respiratory syndrome virus-like particle contains ORF5 protein of sequence number 4 and ORF6 protein of sequence number 5. An antigen formulatioin contains the particles, adjuvants, or immune stimulators and is used by oral, intradermic, intranasal, intramuscular, abdominal, intravenous, or percutaneous administration to vertebrate. A vaccine contains the particles. The vaccine is manufactured in a formulation together with an adjuvant and immune stimulator. A method for inducing immunity against the virus comprises a step of administering the antigen formulation to human or animal. |