摘要 |
<p>This invention relates to novel compounds of the Formula (I), (II), (II-A), (II-B), (II-C), (II-D), (III). (III-A). (IIII-B). (III-C). (III-D), (III-E) (IV), (IV-A), (IV-B). (IV-C), (IV-D). (V), (V-A), (V-B), (V-C), (V-D), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.</p> |
申请人 |
VITAE PHARMACEUTICALS, INC. |
发明人 |
CLAREMON, DAVID A.;LEFTHERIS, KATERINA;SINGH, SURESH B.;TICE, COLIN M.;YE, YUANJIE;ZHUANG, LINGHANG;ZHAO, WEI |