发明名称 |
PI-KINASE INHIBITORS WITH BROAD SPECTRUM ANTI-INFECTIVE ACTIVITY |
摘要 |
Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribivarin, and the like. |
申请公布号 |
EP2763532(A1) |
申请公布日期 |
2014.08.13 |
申请号 |
EP20120838386 |
申请日期 |
2012.10.05 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CHOONG, INGRID;GLENN, JEFFREY S.;GELMAN, MICHAEL A.;TAVSHANJIAN, BRANDON;SHOKAT, KEVAN |
分类号 |
C07D277/44;C07D277/40;C07D277/42;C07D277/46;C07D417/12 |
主分类号 |
C07D277/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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