The present invention relates to nociceptin peptide mimetics that have α-helical structures and bind to and modulate the opioid receptor-like-1 (ORL-1) receptor. The peptide mimetics are constrained cyclic nociceptin analogs which have either agonist or antagonist activity. Pharmaceutical compositions comprising the nociceptin peptide mimetics and methods of treating or preventing a disease or condition ameliorated by modulating the ORL-1 receptor are also described.
申请公布号
EP2576598(A4)
申请公布日期
2014.08.13
申请号
EP20110791746
申请日期
2011.06.07
申请人
THE UNIVERSITY OF QUEENSLAND
发明人
FAIRLIE, DAVID;HARRISON, ROSEMARY SHARON;SHEPHERD, NICHOLAS EVAN