Synergistic effects between sphingosine-1-phosphate receptor antagonists and antimicrotubule agents

摘要

This invention is based on the discovery that the administration of a sphingosine-1-phosphate receptor antagonist (S1P) and at least one chemotherapeutic agent selected from the the group of antimicrotubule agents provides an unexpectedly superior treatment for cancer. Antimicrobial agents such as the taxane compounds are known in the art, for example, paclitaxel (available as TAXOL® from Bristol-Myers Squibb, Princeton, N.J.), docetaxel (available as TAXOTERE® from Sanofi-aventis, Bridgewater, N.J.) and the like and other compounds that act as antimicrotubule agents, such as Vincristine (ONCOVIN®, VINCASAR PFS®, VCR), Vinblastin (VELBAN®, VELSAR®) and Vinorelbine, and similar compounds. The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of at least one sphingosine-1-phosphate 1 (S1P1R) receptor antagonists, and at least one antimicrotubule agent.

主权项

1. A pharmaceutical composition comprising a synergistic combination of at least one S1P1R receptor antagonist and at least one antimicrotubule agent, wherein the S1P1R receptor antagonist is selected from the group of compounds consisting of
1) (S)-2-(2-(1H-imidazol-5-yl)acetamido)-5-phenyl-N-(4-phenoxyphenyl)pentanamide; 2) (2S,4R)-1-(2-(1H-1,2,3-triazol-1-yl)acetyl)-4-(2-chloro-4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 3) (2S,4R)-5-(2-(1H-1,2,3-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(4-methylbenzyl)pyrrolidine-2-carboxamide; 4) (2S,4R)-5-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(4-methylbenzyl)pyrrolidine-2-carboxamide; 5) (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-(2-chloro-4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 6) (2S,4R)-1-(2-(1H-1,2,3-triazol-1-yl)acetyl)-4-(4-fluoro-2-methylbenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 7) (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-(4-fluoro-2-methylbenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 8) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(4-fluoro-2-methylbenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 9) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(2-chloro-4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 10) (2S,4R)-1-(2-(1H-1,2,3-triazol-1-yl)acetyl)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 11) (2S,4R)-1-(2-(5-amino-3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl)acetyl)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 12) 1-((2S,4R)-4-benzyl-2-(5-(4-fluorophenoxy)-1H-benzo[d]imidazol-2-yl)pyrrolidin-1-yl)-2-(1H-1,2,4-triazol-1-yl)ethanone; 13) 3-(benzyloxy)-2-((S)-3-hydroxy-3-phenylpropanamido)-N-(4-phenoxyphenyl)propanamide; 14) 3-(benzyloxy)-2-(2-(furan-2-yl)-2-oxoacetamido)-N-(4-phenoxyphenyl)propanamide; 15) N-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-yl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide; 16) 3-(benzyloxy)-2-(2-hydroxy-2-(2-hydroxyphenyl)acetamido)-N-(4-phenoxyphenyl)propanamide; 17) 4-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-ylcarbamoyl)phenyl acetate; 18) N-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-yl)-5-methylnicotinamide; 19) 3-(benzyloxy)-2-(2-(methylsulfonyl)acetamido)-N-(4-phenoxyphenyl)propanamide; 20) N-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-yl)-1H-indole-5-carboxamide; 21) N-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-yl)-2-bromo-5-fluorobenzamide; 22) N-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-yl)-3,3,3-trifluoropropanamide; 23) (2R)-N-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-yl)tetrahydrofuran-2-carboxamide; 24) 3-(benzyloxy)-2-((R)-2-(2-chlorophenyl)-2-hydroxyacetamido)-N-(4-phenoxyphenyl)propanamide; 25) (2S)-1-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-ylamino)-1-oxopropan-2-yl acetate; 26) 3-(benzyloxy)-2-(2-(2-hydroxyphenoxy)acetamido)-N-(4-phenoxyphenyl)propanamide; 27) 3-(benzyloxy)-2-((R)-2-hydroxy-3-phenylpropanamido)-N-(4-phenoxyphenyl)propanamide; 28) N-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-yl)-2-(methylthio)nicotinamide; 29) N-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-yl)-1-(4-chlorobenzyl)-5-oxopyrrolidine-3-carboxamide; 30) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-((1-methyl-1H-indol-2-yl)methylamino)acetyl)pyrrolidine-2-carboxamide; 31) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-phenylacetyl)pyrrolidine-2-carboxamide; 32) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(3-methylisoxazol-5-yl)acetyl)pyrrolidine-2-carboxamide; 33) (2S,4R)-4-benzyl-1-(4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)butanoyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 34) 34,(2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(3,3,3-trifluoropropanoyl)pyrrolidine-2-carboxamide; 35) (2S,4R)-4-benzyl-1-(2-(4-(dimethylamino)phenyl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 36) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(tetrahydrofuran-3-carbonyl)pyrrolidine-2-carboxamide; 37) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(2-methyl-1H-indol-3-yl )acetyl)pyrrolidine-2-carboxamide; 38) (2S,4R)-4-benzyl-1-(2-butoxyacetyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 39) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-((S)-5-oxotetrahydrofuran-2-carbonyl)pyrrolidine-2-carboxamide; 40) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-((R)-2-hydroxy-2-phenylacetyl)pyrrolidine-2-carboxamide; 41) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(pyrimidin-2-yl)piperazin-1-yl)acetamido)propanamide; 42) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(3-methoxyphenyl)piperazin-1-yl)acetamido)propanamide; 43) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(pyrrolidin-1-yl)piperidin-1-yl)acetamido)propanamide; 44) (S)-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(2-phenyloxazol-4-yl)acetamido)propanamide; 45) (2S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(octahydroquinolin-1(2H)-yl)acetamido)propanamide; 46) (2S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(3-methylpiperidin-1-yl)acetamido)propanamide; 47) (S)-2-(2-(1H-imidazol-5-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)-2-methylphenyl)propanamide; 48) (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(2-methylbenzyl)pyrrolidine-2-carboxamide; 49) (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-(3-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 50) (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-(4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 51) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(3-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 52) (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-(2,4-difluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 53) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(2,4-difluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 54) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(2-(trifluoromethyl)benzyl)pyrrolidine-2-carboxamide; 55) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(2-methylbenzyl)pyrrolidine-2-carboxamide; 56) (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-(2-chlorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 57) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(2-chlorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 58) (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 59) (R)-N-(2-(benzyloxy)-1-(5-(4-fluorophenoxy)-1H-benzo[d]imidazol-2-yl)ethyl)-2-(1H-imidazol-4-yl)acetamide; 60) (R)-N-(2-(benzyloxy)-1-(5-(4-fluorophenoxy)-1H-benzo[d]imidazol-2-yl)ethyl)acetamide; 61) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(3-chlorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 62) (2S,4S)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(4-methoxyphenyl)pyrrolidine-2-carboxamide; 63) (2S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(2-methylpyrrolidin-1-yl)acetamido)propanamide; 64) (2S,4S)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(thien-2-ylmethyl)pyrrolidine-2-carboxamide; 65) (2S,4S)-1-(2-(1H-1,2,3-triazol-1-yl)acetyl)-4-((5-chlorothien-2-yl)methyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 66) (2S,4S)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-((5-chlorothien-2-yl)methyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 67) (2S,4S)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-((5-chlorothien-2-yl)methyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 68) (2S,4R)-1-(2-(1H-1,2,3-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(3-methoxybenzyl)pyrrolidine-2-carboxamide; 69) (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(3-methoxybenzyl)pyrrolidine-2-carboxamide; 70) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(3-methoxybenzyl)pyrrolidine-2-carboxamide; 71) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)-5-oxopyrrolidine-2-carboxamide; 72) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(thiophen-3-ylmethyl)pyrrolidine-2-carboxamide; 73) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluoro-3-methylphenoxy)phenyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxamide; 74) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluoro-2-methylphenoxy)phenyl)-4-(4-fluorobenzyl)pyrrolidine-2-carboxamide; 75) (2S,4R)-1-(2-(1H-1,2,3-triazol-1-yl)acetyl)-4-(4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 76) (2S,4S)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 77) (2S,4S)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-phenylpyrrolidine-2-carboxamide; 78) (2S,4S)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-phenylpyrrolidine-2-carboxamide; 79) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-benzyl-N-(4-(4-chlorophenoxy)phenyl)pyrrolidine-2-carboxamide; 80) (2S,4S)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(benzylamino)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 81) (S)-3-(benzyloxy)-2-(3-(3-chloro-4-methoxyphenyl)propanamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 82) (2S,4R)-4-benzyl-1-(2-(3,4-dihydroisoquinolin-2(1H)-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 83) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-thiomorpholinoacetyl)pyrrolidine-2-carboxamide; 84) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(2,3,6-trifluorophenyl)acetyl)pyrrolidine-2-carboxamide; 85) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(3-(methylthio)propanoyl)pyrrolidine-2-carboxamide; 86) (2S,4R)-4-benzyl-1-(3-ethoxypropanoyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 87) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(methylsulfonyl)acetyl)pyrrolidine-2-carboxamide; 88) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(2-methoxyethoxy)acetyl)pyrrolidine-2-carboxamide; 89) (2S,4R)-4-benzyl-1-(4-(dimethylamino)-4-oxobutanoyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 90) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(3-methoxypropanoyl)pyrrolidine-2-carboxamide; 91) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(4-oxo-4-(thien-2-yl)butanoyl)pyrrolidine-2-carboxamide; 92) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(tetrahydrofuran-2-carbonyl)pyrrolidine-2-carboxamide; 93) (2S,4R)-1-((S)-1-acetylpyrrolidine-2-carbonyl)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 94) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(pyrimidin-2-ylthio)acetyl)pyrrolidine-2-carboxamide; 95) (2S,4R)-4-benzyl-1-(2-(2,6-difluorophenyl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 96) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(pyridin-4-ylthio)acetyl)pyrrolidine-2-carboxamide; 97) (2S,4R)-4-benzyl-1-(2-(1,3-dioxo-2,3-dihydro-1H-inden-2-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 98) (2S,4R)-1-(2-(1H-indol-3-yl)acetyl)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 99) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(4-oxo-2-thioxothiazolidin-3-yl)acetyl)pyrrolidine-2-carboxamide; 100) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(4-(2-methoxyethyl)piperazin-1-yl)acetyl)pyrrolidine-2-carboxamide; 101) (S)-3-(benzyloxy)-2-(2-(3-fluoro-4-(trifluoromethyl)phenyl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 102) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(3-(trifluoromethoxy)phenyl)acetamido)propanamide; 103) (S)-tert-butyl 1-(2-((S)-3-(benzyloxy)-1-(4-(4-fluorophenoxy)phenylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)pyrrolidine-2-carboxylate; 104) (S)-N-(3-(benzyloxy)-1-(4-(4-fluorophenoxy)phenylamino)-1-oxopropan-2-yl)-5-phenylpentanamide; 105) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-morpholinopiperidin-1-yl)acetamido)propanamide; 106) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(2-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 107) (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-(2-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 108) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(2,4,6-trifluorobenzyl)pyrrolidine-2-carboxamide; 109) (2S)-3-(benzyloxy)-2-(2-(3-(diethylamino)pyrrolidin-1-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 110) (2S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)acetamido)propanamide; 111) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-isopropylpiperazin-1-yl)acetamido)propanamide; 112) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)acetamido)propanamide; 113) (2S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(2(((S)-1-methylpyrrolidin-2-yl)methyl)piperidin-1-yl)acetamido)propanamide, 114) (S)-3-(benzyloxy)-2-(2-(4-ethylpiperazin-1-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 115) (2S,4R)-1-(2-(4-acetylpiperazin-1-yl)acetyl)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 116) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-morpholinoacetyl)pyrrolidine-2-carboxamide; 117) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(thien-2-yl)acetyl)pyrrolidine-2-carboxamide; 118) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(3-hydroxybutanoyl)pyrrolidine-2-carboxamide; 119) (2S,4R)-4-benzyl-1-(2-(2,6-dichlorophenyl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 120) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-hydroxyacetyl)pyrrolidine-2-carboxamide; 121) (2S,4R)-4-benzyl-1-(2-ethoxyacetyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 122) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-methoxyacetyl)pyrrolidine-2-carboxamide; 123) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(4-oxopentanoyl)pyrrolidine-2-carboxamide; 124) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(4-oxo-4-phenylbutanoyl)pyrrolidine-2-carboxamide; 125) methyl 4-((2S,4R)-4-benzyl-2-(4-(4-fluorophenoxy)phenylcarbamoyl)pyrrolidin-1-yl)-4-oxobutanoate; 126) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(pyridin-2-yl)piperazin-1-yl)acetamido)propanamide; 127) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(2-fluorophenyl)piperazin-1-yl)acetamido)propanamide; 128) (S)-2-(2-(azepan-1-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 129) (2S,4R)-4-benzyl-1-(2-cyanoacetyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 130) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-methylpiperidin-1-yl)acetamido))propanamide; 131) (S)-2-(2-(1H-imidazol-5-yl)acetamido)-3-benzyloxy-N-(4-(4-fluorophenoxy)phenyl)propanamide; 132) (S)-2-(2-(1H-imidazol-5-yl)acetamido)-3-(4-fluorobenzyloxy)-N-(4-(4-chlorophenoxy)phenyl)propanamide; 133) (S)-2-(2-(1H-imidazol-5-yl)acetamido)-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 134) (S)-2-(2-(1H-imidazol-1-yl)acetamido)-3-benzyloxy-N-(4-(4-fluorophenoxy)phenyl)propanamide; 135) (S)-2-(2-(1H-1,2,4-triazol-1-yl)acetamido)-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 136) (S)-3-(benzyloxy)-2-(2-chloroacetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 137) (S)-2-(2-(1H-imidazol-5-yl)acetamido)-5-phenyl-N-(4-(4-fluorophenoxy)phenyl)pentanamide; 138) (S)-2-(2-(2H-1,2,3-triazol-2-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 139) (S)-2-(2-(1H-1,2,4-triazol-1-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)-3-(2-(trifluoromethoxy)benzyloxy)propanamide; 140) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 141) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(4-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 142) 2-(2-(1H-imidazol-5-yl)acetamido)-3-benzyloxy-N-(4-phenoxyphenyl)propanamide; 143) (S)-2-(2-(1H-imidazol-5-yl)acetamido)-3-benzyloxy-N-(4-phenoxyphenyl)propanamide; 144) (S)-2-(2-(1H-tetrazol-1-yl)acetamido)-3-benzyloxy-N-(4-phenoxyphenyl)propanamide; 145) (S)-2-(2-(1H-imidazol-5-yl)acetamido)-3-benzyloxy-N-(4-(4-chlorophenoxy)phenyl)propanamide; 146) (S)-2-(2-(1H-1,2,4-triazol-1-yl)acetamido)-3-(benzyloxy)-N-(4-phenoxyphenyl)propanamide; 147) (S)-2-(2-(1H-imidazol-4-yl)acetamido)-3-(benzyloxy)-N-(3-chloro-4-phenoxyphenyl)propanamide; 148) (S)-2-(2-(1H-imidazol-4-yl)acetamido)-3-(benzyloxy)-N-(4-(3-chlorophenoxy)phenyl)propanamide; 149) (S)-2-(2-(1H-1,2,4-triazol-1-yl)acetamido)-3-benzyloxy-N-(4-(4-fluorophenoxy)phenyl)propanamide; 150) (S)-3-(benzyloxy)-2-(2-(3,5-dimethylisoxazol-4-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 151) (S)-2-(2-(1H-benzo [d][1,2,3]triazol-1-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 152) (S)-3-(benzyloxy)-2-(2-(3,5-dimethyl-1H-pyrazol-4-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 153) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-methyl-1H-1,2,3-triazol-1-yl)acetamido)propanamide; 154) (S)-2-(2-(1H-imidazol-4-yl)acetamido)-3-(benzyloxy)-N-(3-chloro-4-(4-chlorophenoxy)phenyl)propanamide; 155) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-morpholinoacetamido)propanamide; 156) (S)-2-(2-(1H-imidazol-4-yl)acetamido)-3-(benzyloxy)-N-(4-(5-bromothiazol-2-yloxy)phenyl)propanamide; 157) (S)-2-(2-(1H-imidazol-5-yl)acetamido)-N-(4-(4-chlorophenoxy)phenyl)-4-phenylbutanamide; 158) (S)-2-(2-(1H-imidazol-5-yl)acetamido)-3-(benzyloxy)-N-(4-(p-tolyloxy)phenyl)propanamide; 159) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(pyrazin-2-yl)acetamido)propanamide; 160) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(2-methyl-1H-imidazol-1-yl)acetamido)propanamide; 161) (S)-2-(2-(1H-imidazol-4-yl)-2-methylpropanamido)-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 162) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(2-methyl-1H-imidazol-4-yl)acetamido)propanamide; 163) (2S,3S)-1-(2-(1H-imidazol-4-yl)acetyl)-3-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 164) (S)-2-acetamido-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 165) (S)-benzyl 4-(2-(1H-1,2,4-triazol-1-yl)acetamido)-5-(4-(4-fluorophenoxy)phenylamino)-5-oxopentylcarbamate; 166) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(3-methyl-1H-pyrazol-5-yl)acetamido)propanamide 167) (2S)-2-(2-(1H-imidazol-4-yl)propanamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 168) (S)-2-(2-(1H-imidazol-5-yl)acetamido)-N-(4-(4-bromophenoxy)phenyl)-3-(4-fluorobenzyloxy)propanamide; 169) (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(2,4,6-trifluorobenzyl)pyrrolidine-2-carboxamide; 170) (2S,4R)-1-(2-(1H-1,2,3-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(2,4,6-trifluorobenzyl)pyrrolidine-2-carboxamide; 171) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(3-methylbenzyl)pyrrolidine-2-carboxamide; 172) (S)-2-(3-(3,5-dimethylisoxazol-4-yl)ureido)-3-benzyloxy-N-(4-(4-fluorophenoxy)phenyl)propanamide; 173) (2S,4R)-1-(2-(1H-imidazol-5-yl)acetyl)-4-(benzylamino)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 174) (S)-2-(2-(1H-1,2,3-triazol-1-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 175) 175 (S)-1-(2-(1H-imidazol-4-yl)acetyl)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)piperazine-2-carboxamide; 176) (2S,4R)-1-(2-(1H-benzo[d][1,2,3]triazol-1-yl)acetyl)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 177) (2S,4R)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)-1-(2-(5-methyl-1H-pyrazol-3-yl)acetyl)pyrrolidine-2-carboxamide; 178) (S)-2-(2-(1H-1,2,4-triazol-1-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenylthio)phenyl)propanamide; 179) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(benzylamino)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 180) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(2,4-dichlorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 181) (S)-2-(2-(1H-1,2,4-triazol-1-yl)acetamido)-3-(2-chlorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 182) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(thien-3-ylmethylamino)pyrrolidine-2-carboxamide; 183) 3-(benzyloxy)-2-(2-(2-fluorophenyl)acetamido)-N-(4-phenoxyphenyl)propanamide; 184) N-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-yl)-1H-indole-4-carboxamide; 185) 2-(2-(3-methylisoxazol-5-yl)acetamido)-3-benzyloxy-N-(4-phenoxyphenyl)propanamide; 186) N-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-yl)-4-cyclopropyl-4-oxobutanamide; 187) N-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-yl)-1H-indole-6-carboxamide; 188) N-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-yl)-2,3-dihydro-1H-indene-2-carboxamide; 189) N-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-yl)-3-methyl-2-nitrobenzamide; 190) 3-(benzyloxy)-2-(2-(2,5-dichlorophenyl)acetamido)-N-(4-phenoxyphenyl)propanamide; 191) 3-(benzyloxy)-2-(2-(3-chloro-2-fluorophenyl)acetamido)-N-(4-phenoxyphenyl)propanamide; 192) 3-(benzyloxy)-2-(2-(5-chloro-2-fluorophenyl)acetamido)-N-(4-phenoxyphenyl)propanamide; 193) 2-(2-(1-acetylpyrrolidin-2-yl)acetamido)-3-benzyloxy-N-(4-phenoxyphenyl)propanamide; 194) (S)-2-{2-((benzoyl)(methyl)amino)acetamido}-3-benzyloxy-N-(4-phenoxyphenyl)propanamide; 195) (S)-2-(2-(1-methyl-1H-imidazol-4-yl)acetamido)-3-benzyloxy-N-(4-phenoxyphenyl)propanamide; 196) (S)-2-(2-(2-fluorophenyl)acetamido)-3-benzyloxy-N-(4-phenoxyphenyl)propanamide; 197) (S)-2-(2-(1H-indol-4-yl)acetamido)-3-benzyloxy-N-(4-phenoxyphenyl)propanamide; 198) (S)-2-(2-(thien-2-yl)acetamido)-3-benzyloxy-N-(4-phenoxyphenyl)propanamide; 199) (S)-2-(2-(2,5-dichlorophenyl)acetamido)-3-benzyloxy-N-(4-phenoxyphenyl)propanamide; 200) (S)-2-(2-(1H-imidazol-4-yl)acetamido)-3-(benzyloxy)-N-(4-benzylphenyl)propanamide; 201) (S)-3-(benzyloxy)-2-(2-(2,4-dioxoimidazolidin-1-yl)acetamido)-N-(4-phenoxyphenyl)propanamide; 202) (S)-2-(2-(1H-imidazol-4-yl)acetamido)-3-(benzyloxy)-N-(4-(4-methoxyphenoxy)phenyl)propanamide; 203) (S)-2-(2-(1H-imidazol-4-yl)-N-methylacetamido)-3-(benzyloxy)-N-(4-phenoxyphenyl)propanamide; 204) (S)-2-(2-(1H-imidazol-5-yl)acetamido)-N-(4-(4-chlorophenoxy)phenyl)-3-phenylpropanamide; 205) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(piperazin-1-yl)acetamido)propanamide; 206) (S)-2-(2-(1H-imidazol-4-yl)acetamido)-3-(benzyloxy)-N-(4-(thiazol-2-yloxy)phenyl)propanamide; 207) (S)-2-(3-(1H-imidazol-5-yl)propanamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 208) (S)-2-(2-(1H-imidazol-5-yl)acetamido)-3-(benzyloxy)-N-(4-(cyclohexyloxy)phenyl)propanamide; 209) (S)-3-(benzyloxy)-N-(4-(4-chlorophenoxy)phenyl)-2-(3-(dimethylamino)propanamido)propanamide; 210) (S)-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-morpholinoacetamido)propanamide; 211) (S)-2-(2-(1H-imidazol-4-yl)acetamido)-3-(benzyloxy)-N-(4-(benzyloxy)phenyl)propanamide; 212) (S)-3-(benzyloxy)-2-(2-(5-fluoro-1H-indol-3-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 213) (S)-2-(2-(1H-imidazol-4-yl)-2-methylpropanamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 214) (S)-3-(benzyloxy)-2-(2-(2,5-dihydro-1H-pyrrol-1-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 215) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(pyrrolidin-1-yl)acetamido)propanamide; 216) (S)-2-(2-(2-(1H-imidazol-4-yl)ethylamino)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 217) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(2-methoxyphenyl)piperazin-1-yl)acetamido)propanamide; 218) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(4-fluorophenyl)piperazin-1-yl)acetamido)propanamide; 219) (2S)-2-(2-(2,3-dioxa-8-azaspiro[4.5]decan-8-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 220) (S)-3-(benzyloxy)-2-(2-(4-benzylpiperidin-1-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 221) (S)-3-(benzyloxy)-2-(2-(3,4-dihydroisoquinolin-2(1H)-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 222) (2S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(octahydroisoquinolin-2(1H)-yl)acetamido)propanamide; 223) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(furan-2-carbonyl)piperazin-1-yl)acetamido)propanamide; 224) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(4-methoxyphenyl)piperazin-1-yl)acetamido)propanamide; 225) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-phenylpiperazin-1-yl)acetamido)propanamide; 226) (2S,4R)-1-(2-(1H-1,2,3-triazol-1-yl)acetyl)-4-(3,4-difluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 227) (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-(4-chlorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 228) (2S,4R)-1-(2-(1H-1,2,3-triazol-1-yl)acetyl)-4-(4-chlorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 229) (S)-2-(2-(4-(4-acetylphenyl)piperazin-1-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 230) (S)-2-(2-(4-acetylpiperazin-1-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 231) 1-(2-((S)-3-(benzyloxy)-1-(4-(4-fluorophenoxy)phenylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)-N,N-diethylpiperidine-3-carboxamide; 232) (S,E)-N-(3-(benzyloxy)-1-(4-(4-fluorophenoxy)phenylamino)-1-oxopropan-2-yl)hex-3-enamide; 233) (S)-N-(3-(benzyloxy)-1-(4-(4-fluorophenoxy)phenylamino)-1-oxopropan-2-yl)-3-methylbutanamide; 234) (S)-3-(benzyloxy)-2-(2-((2R,6S)-2,6-dimethylmorpholino)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 235) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(thiazolidin-3-yl)acetamido)propanamide; 236) (S)-2-(2-(4-acetylpiperazin-1-yl)acetamido)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 237) (2S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(tetrahydrofuran-2-carbonyl)piperazin-1-yl)acetamido)propanamide; 238) (S)-methyl 1-(2-(3-(benzyloxy)-1-(4-(4-fluorophenoxy)phenylamino)-1-oxopropan-2-ylamino)-2-oxoethyl)piperidine-4-carboxylate; 239) (S)-3-(benzyloxy)-2-(2-(4-(2-chloro-6-fluorobenzyl)piperazin-1-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 240) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(isoindolin-2-yl)acetamido)propanamide; 241) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(2-methoxyethyl)piperazin-1-yl)acetamido)propanamide; 242) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(4-(2-ethoxyethyl)piperazin-1-yl)acetamido)propanamide; 243) (S)-2-(2-(1H-imidazol-4-yl)acetamido)-3-(benzyloxy)-N-(3-phenoxyphenyl)propanamide; 244) (S)-3-(benzyloxy)-2-(2-(3-bromophenyl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 245) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(3-nitropropanamido)propanamide; 246) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(pyridin-2-yl)acetamido)propanamide; 247) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(pyridin-3-yl)acetamido)propanamide; 248) (S)-N-((S)-3-(benzyloxy)-1-(4-(4-fluorophenoxy)phenylamino)-1-oxopropan-2-yl)-3,7-dimethyloct-6-enamide; 249) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-phenylacetamido)propanamide; 250) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-(pyrimidin-5-yl)acetamido)propanamide; 251) (2S,4S)-1-(2-(1H-imidazol-5-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-phenylpyrrolidine-2-carboxamide; 252) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-(benzyloxy)-N-(4-(4-fluorohenoxy)phenyl)pyrrolidine-2-carboxamide; 253) benzyl (3R,5S)-1-(2-(1H-imidazol-5-yl)acetyl)-5-(4-(4-fluorophenoxy)phenylcarbamoyl)pyrrolidin-3-ylcarbamate; 254) (S)-2-(2-(1H-1,2,4-triazol-1-yl)acetamido)-5-acetamido-N-(4-(4-fluorophenoxy)phenyl)pentanamide; 255) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-methyl-2-(1H-1,2,4-triazol-1-yl)propanamido)propanamide; 256) (S)-3-(benzyloxy)-2-(2-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 257) (S)-benzyl 4-(2-(1H-imidazol-4-yl)acetyl)-3-(4-(4-fluorophenoxy)phenylcarbamoyl)piperazine-1-carboxylate; 258) (S)-2-(2-(3,5-dimethyl-1H-pyrazol-4-yl)acetamido)-3-(4-fluorobenzyloxy)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 259) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-phenoxypyrrolidine-2-carboxamide; 260) (2S,4R)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(isoindolin-2-pyrrolidine-2-carboxamide; 261) (S)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-benzyl-N-(4-(4-fluorophenoxy)phenyl)piperazine-2-carboxamide; 262) (2S,4S)-1-(2-(1H-1,2,4-triazol-1-yl)acetyl)-4-((benzylamino)methyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 263) (2S,4R)-1-(2-(1H-1,2,3-triazol-1-yl)acetyl)-4-(3-chlorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 264) (2S,4R)-1-(2-(1H-1,2,3-triazol-1-yl)acetyl)-4-(2-fluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 265) (2S)-3-(benzyloxy)-2-(2-(2,6-dimethylmorpholino)acetamido)-N-(4-(4-fluorophenoxy)phenyl)propanamide; 266) (S)-3-(benzyloxy)-N-(4-(4-fluorophenoxy)phenyl)-2-(2-thiomorpholinoacetamido)propanamide; 267) (2S,4R)-1-(2-(1H-1,2,3-triazol-1-yl)acetyl)-4-(2,4-difluorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 268) (2S,4R)-1-(2-(2H-1,2,3-triazol-2-yl)acetyl)-4-(3-chlorobenzyl)-N-(4-(4-fluorophenoxy)phenyl)pyrrolidine-2-carboxamide; 269) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)acetamide; 270) 4-(methyloxy)-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 271) 4-benzyloxy-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)phenylacetamide; 272) 2-bromo-5-(methyloxy)-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 273) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)butanamide; 274) 2-chloro-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 275) 3-chloro-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 276) 4-chloro-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 277) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)cyclopropylamide; 278) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-3-cyclopentylpropanamide; 279) 3,4-dimethyl-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 280) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2,5-dimethoxyphenylacetamide; 281) 4-(ethyloxy)-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 282) N-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-yl)-2-ethylhexanamide; 283) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)furan-2-carboxamide; 284) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-methoxyacetamide; 285) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-3-methoxyphenylacetamide; 286) 2-methyl-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)pentanamide; 287) 4-methyl-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)pentanamide; 288) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)naphthalene-2-carboxamide; 289) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)phenoxyacetamide; 290) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(phenyloxy)pyridine-3-carboxamide; 291) 3,4,5-tris(methyloxy)-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 292) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)thiophene-2-carboxamide; 293) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)thien-2-ylacetamide; 294) 4-(dimethylamino)-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 295) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)hexanamide; 296) 2-chloro-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)pyridine-3-carboxamide; 297) 3-chloro-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-1-benzothiophene-2-carboxamide; 298) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)pent-4-enamide; 299) 3-chloro-2-fluoro-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 300) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-4-phenylbutanamide; 301) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-bromophenylacetamide; 302) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-1-[4-(trifluoromethyl)pyrimidin-2-yl]piperidine-4-carboxamide; 303) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-methoxyethoxyacetamide; 304) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-3-(4-methoxyphenyl)propanamide; 305) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-acetylamino-4-methylthiazol-5-ylsulfonamide; 306) 4-(methylthio)-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 307) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(methylthio)acetamide; 308) 5-fluoro-2-(methyloxy)-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 309) 2-methyl-4-(methyloxy)-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 310) 5-oxo-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)hexanamide; 311) 4-bromo-2-methyl-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 312) 4-oxo-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-4-(2-thienyl)butanamide; 313) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(phenylthio)acetamide; 314) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(1H-pyrrol-1-yl)benzamide; 315) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-[2-(methoxy)ethoxy]ethoxyacetamide; 316) 3,5-bis(methyloxy)-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 317) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-3-cyclohexylpropanamide; 318) 5-oxo-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-5-phenylpentanamide; 319) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-4-acetylphenoxyacetamide; 320) 4-[3,4-bis(methyloxy)phenyl]-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)butanamide; 321) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-5-[3-(trifluoromethyl)phenyl]furan-2-carboxamide; 322) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-3-(1,3-dioxoisoindolin-2-yl)propanamide; 323) 5-oxo-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-5-(2-thienyl)pentanamide; 324) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-oxo-2-phenylacetamide; 325) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-4-(2-thienyl)butanamide; 326) 5-nitro-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)furan-2-carboxamide; 327) (E)-N-(3-(benzyloxy)-1-oxo-1-(4-phenoxyphenylamino)propan-2-yl)hex-3-enamide 328) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-1,3-benzodioxol-5-ylacetamide; 329) 1-(2-chloro-6-fluorophenyl)-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)cyclopentanecarboxamide; 330) 4-fluoro-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(trifluoromethyl)benzamide; 331) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(pyrimidin-2-ylthio)acetamide; 332) 2,5-bis(methyloxy)-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 333) 4-(methylsulfonyl)-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 334) 2-chloro-4-(methylsulfonyl)-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 335) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)2-(4-oxo-2-thioxothiazolidin-3-yl)acetamide; 336) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)tetrahydrofuran-3-carboxamide; 337) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-3-methoxypropanamide; 338) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-ethoxyacetamide; 339) N,N-dimethyl-N′-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)butanediamide; 340) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-N-benzoyl-N-methylaminoacetamide; 341) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-1H-indole-3-carboxamide; 342) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-1H-benzimidazole-5-carboxamide; 343) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(4-ethoxyphenyl)acetamide; 344) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)pent-4-ynamide; 345) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-4-(propyloxy)benzamide; 346) 2-methyl-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)hexanamide; 347) 4-oxo-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)pentanamide; 348) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-3-(3,4-dimethoxyphenyl)propanamide; 349) 4-oxo-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-4-phenylbutanamide; 350) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)quinoline-3-carboxamide; 351) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)pyrazine-2-carboxamide; 352) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(5-methoxy-2-methyl-1H-indol-3-yl)acetamide; 353) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-methoxy-2-phenylacetamide; 354) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2R-phenylpropanamide; 355) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-1H-pyrazole-4-carboxamide; 356) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)cinnoline-4-carboxamide; 357) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)quinoline-8-carboxamide; 358) 6-hydroxy-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)pyridine-2-carboxamide; 359) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-phenylpropanamide; 360) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-1-(4-methoxyphenyl)cyclopropanecarboxamide; 361) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(2,3,6-trifluorophenyl)acetamide; 362) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2,4-bis(trifluoromethyl)benzamide; 363) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(2,4-difluorophenyl)acetamide; 364) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4(phenyloxy)phenyl]amino}ethyl)-2-(1-methyl-1H-indol-3-yl)acetamide; 365) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)quinoline-4-carboxamide; 366) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-1-benzofuran-2-carboxamide; 367) 7-(methyloxy)-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-1-benzofuran-2-carboxamide; 368) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(4-fluorophenoxy)acetamide; 369) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-3-(pyridin-3-yl)propanamide; 370) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(3,4-dichlorophenoxy)acetamide; 371) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(naphthalen-1-yloxy)acetamide; 372) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-p-tolylacetamide; 373) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(2,5-dimethylphenyl)acetamide; 374) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(benzylthio)acetamide; 375) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(naphthalen-1-yl)acetamide; 376) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-3-ethoxypropanamide; 377) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(3-chlorophenyl)acetamide; 378) 5-butyl-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)pyridine-2-carboxamide; 379) 4-chloro-3-methyl-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 380) 4-cyano-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 381) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2S-methoxy-2-phenylacetamide; 382) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-3-(2,5-dimethoxyphenyl)propanamide; 383) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-3-(1H-indol-3-yl)propanamide; 384) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(3-bromophenyl)acetamide; 385) 3-methyl-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)pentanamide; 386) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-1H-indole-2-carboxamide; 387) 4-chloro-2-fluoro-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 388) 2-oxo-2-[(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)amino]ethyl acetate; 389) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)thiophene-3-carboxamide; 390) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(4-bromophenyl)acetamide; 391) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(2-chlorophenyl)acetamide; 392) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(3,4,5-trimethoxyphenyl)acetamide; 393) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-2-(p-tolyloxy)acetamide; 394) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-3-(2-methoxyphenyl)propanamide; 395) 3-hydroxy-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)quinoxaline-2-carboxamide; 396) 4-acetyl-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 397) methyl 4-{[(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)amino]carbonyl}benzoate; 398) 3-fluoro-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-5-(trifluoromethyl)benzamide; 399) 4-[(difluoromethyl)oxy]-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 400) 3-fluoro-4-methyl-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)benzamide; 401) 3-methyl-N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)furan-2-carboxamide. 402) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)cyclobutanecarboxamide; and 403) N-(2-oxo-1-{[(phenylmethyl)oxy]methyl}-2-{[4-(phenyloxy)phenyl]amino}ethyl)-3-(thiophen-2-yl)propanamide.