发明名称 Sulfone-substituted anilinopyrimidine derivatives as CDK inhibitors, the production thereof, and use as a medicine
摘要 The invention relates to sulphone-substituted anilinopyrimidine derivatives of the formula (I),; to its preparation processes, and to its use as medicament for treating various diseases.
申请公布号 US8802686(B2) 申请公布日期 2014.08.12
申请号 US200913125144 申请日期 2009.10.08
申请人 Bayer Intellectual Property GmbH 发明人 Lücking Ulrich;Siemeister Gerhard;Lienau Philip;Jautelat Rolf;Schulze Julia
分类号 A61K31/505;C07D239/24 主分类号 A61K31/505
代理机构 代理人
主权项 1. Compounds of formula (I),in which R1 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C7-cycloalkyl or phenyl, in each case optionally substituted one or more times, identically or differently, with hydroxy, —NR3R4, cyano, halogen, —CF3, C1-C6-alkoxy, —OCF3 or C1-C6-alkyl, R2 is C1-C10-alkyl, C3-C10-alkenyl, C3-C10-alkynyl or C3-C7-cycloalkyl, in each case optionally substituted one or more times, identically or differently, with a) halogen, hydroxy, —NR3R4, cyano, —CF3, or —OCF3, orb) C1-C6-alkoxy, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, —O—CH2-phenyl, or Cn-alkoxycarbonyl,in each case optionally substituted themselves one or more times, identically or differently, with halogen, hydroxy, C1-C6-alkyl, C1-C6-alkoxy, —NR3R4, —CF3 or —OCF3, R3 and R4 independently of one another, are hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C3-C8-cycloalkyl, phenyl, heterocyclyl having 3 to 8 ring atoms, or monocyclic heteroaryl, optionally substituted one or more times, identically or differently, with hydroxy, —NR5R6, cyano, halogen, —CF3, C1-C6-alkoxy or OCF3, or R3 and R4 together with the nitrogen atom, form a 5- to 7-membered ring which, optionally, in addition to the nitrogen atom, contains one or two further heteroatoms and which may be substituted one or more times, identically or differently, with hydroxy, —NR5R6, cyano, halogen, —CF3, C1-C6-alkoxy or —OCF3, and R5 and R6 independently of one another, are hydrogen or C1-C6-alkyl, which is optionally substituted one or more times, identically or differently, with hydroxy, cyano, halogen, —CF3, C1-C6-alkoxy or —OCF3, and salts, diastereomers and enantiomers thereof.
地址 Monheim DE