Solid forms of 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, and their pharmaceutical compositions and uses

摘要

Solid forms comprising 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their uses are disclosed.

主权项

1. A solid form of 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)-piperidine-2,6-dione: or a stereoisomer thereof, or a pharmaceutically acceptable salt, solvate, hydrate, co-crystal, or clathrate thereof; having an X-ray powder diffraction pattern comprising: peaks at approximately 14.6° 2θ, 15.6° 2θ, 16.7° 2θ, 21.9° 2θ and 30.0° 2θ as shown in FIG. 1; peaks at approximately 10.6° 2θ, 14.7° 2θ, 19.1° 2θ and 25.9° 2θ as shown in FIG. 4; peaks at approximately 10.8° 2θ, 15.1° 2θ, 25.1° 2θ and 26.6° 2θ as shown in FIG. 7; peaks at approximately 16.7° 2θ, 21.7° 2θ, 21.9° 2θ and 25.8° 2θ as shown in FIG. 10; peaks at approximately 7.3° 2θ, 14.6° 2θ, 22.0° 2θ, 30.0° 2θ and 37.0° 2θ as shown in FIG. 13; peaks at approximately 14.5° 2θ, 15.7° 2θ, 22.7° 2θ and 29.9° 2θ as shown in FIG. 16; or peaks at approximately 8.6° 2θ, 13.1° 2θ, 20.5° 2θ and 26.3° 2θ as shown in FIG. 18; when analyzed using CuKα X-ray radiation at 1.54 Å.