CD40-L Inhibitory Peptides

摘要

The present invention provides compositions comprising peptidyl inhibitors of CD40L-dependent signalling that are not derived from a natural binding partner of CD40L such as CD40, or from a native CD40-CD40L interface. More particularly, the peptidyl inhibitors of the present invention are derived from natural sources that do not express CD40-CD40L costimulatory pathways. The invention also provides synthetic derivatives and analogs of the peptidyl inhibitors having enhanced binding affinity for CD40L or enhanced inhibitory activity relative to their parent molecules.

主权项

1. A composition comprising one or more peptides wherein the peptide comprises a sequence of amino acids other than the sequence of CD40, binds to CD40 ligand (CD40L), partially or completely inhibits interaction of CD40 with CD40L and one or more CD40-CD40L costimulatory effects and comprises a sequence selected from the group consisting of:
(i) a sequence set forth in any one of SEQ ID NOs: 1, 2, 5, 7, 19, 20, 23, 25, 35, 36, 39, 41 and 42; (ii) a sequence of a peptidyl fusion comprising a plurality of sequences at (i); and (iii) a sequence of (i) additionally comprising a protein transduction domain.