| 摘要 |
A multi-arm, star-shaped polymer composition can be configured for drug delivery and imaging applications in vivo. The star polymer architecture can be synthesized using living radical polymerization techniques, including reversible addition-fragmentation chain transfer and macromolecular design via the interchange of xanthates with a broad range of reaction conditions and functional groups. The star-shaped polymeric carriers can be tailored for preferential delivery of chemotherapeutics into the tumor-draining lymphatics via subcutaneous, peritumoral or intratumoral injections. The carriers can be loaded with the chemotherapeutic agents from about 10% to about 25% w/w. In addition, the carriers can be loaded with imaging agents from about 5% to about 10% w/w. The molecular weights of the polymeric carriers can be about 40 kDa to about 130 kDa. The chemotherapeutics can be cisplatin, geldanamycin or nitric oxide-donating prodrugs. The imaging agent can be a near-infrared dye, such as IR820. |
| 主权项 |
1. A multi-arm compound according to Formula 1: wherein: X is one of carbon (C), oxygen (O), nitrogen (N), phosphorous (P), or sulfur (S); m is 2, 3, 4, 5, 6, 7, or 8 and indicates a total number of arms; Y is alkyl; La are each independently a bond or a linker; Ra are each independently a therapeutic agent, imaging agent, hydrogen, or combinations thereof; na are each independently an integer from 2 to 500; a is a numerical character uniquely identifying each of said arms; wherein when Ra is hydrogen, La is a bond; wherein at least one of Ra is a therapeutic agent, imaging agent, or combinations thereof; and wherein at least one La is a linker including one or more subunits having one or more sugars or carbohydrates. |
