Systems and processes for spray drying hydrophobic and hydrophilic components

摘要

Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions of the components and spray drying them simultaneously in a spray dryer. The hydrophilic and hydrophobic component are separately dissolved in separate solvents and directed simultaneously through a nozzle, usually a coaxial nozzle, into the spray dryer. The method provides dry powders having relatively uniform characteristics.

主权项

1. A dry powder drug composition in the form of a unit dose, the composition comprising discrete particles having an average particle size of less than 10 μm for delivery to the lungs as a dry powder, wherein each discrete particle comprises a drug component, a hydrophobic component having a water solubility of less than 5 mg/mL, and a hydrophilic component having a water solubility of greater than 5 mg/mL, wherein the unit dose is contained in a unit dose receptacle that is insertable into a dry powder inhaler.