| 主权项 |
1. A biodegradable polyamide ester of formula VIII or IX, or a pharmaceutically acceptable salt thereof:
(C) —[(X1)cO(O═)C—R9—C(═O)O—(Y1)d—(Y2)a—CH2(O═)C—NH—R10—NH—C(═O)CH2—(X2)b]o— VIII wherein the polyamide ester of formula VIII is formed by condensation polymerization of monomers of formula Va and VII:
H—(X1)c—O(O═)C—R9—C(═O)O—(Y1)d—H VaR11—(Y2)a—CH2(O═)C—NH—R10—NH—C(═O)CH2—(X2)b—R12 VII(D)—[(X)a—O—R1—O—(Y)b—(Y2)a—CH2(O═)C—NH—R10—NH—C(═O)CH2—(X2)b]p— IX wherein the polyamide ester of formula IX is formed by condensation polymerization of monomers of formula I and VII:
H—(X)a—O—R1—O—(Y)b—H IR11—(Y2)a—CH2(O═)C—NH—R10—NH—C(═O)CH2—(X2)b—R12 VII wherein:
o and p are each independently an integer from about 5 to about 1000;R1 and R9 are each independently the remaining portion of a biologically active compound;R10 is the remaining portion of a biologically active compound or non-biologically active compound;R11 and R12 are each independently selected from Cl, F, Br, and I;X, X1 and X2 are independently at each occurrence —OC(═O)CH2— (inverse glycolic acid moiety), —OC(═O)CH(CH3)— (inverse lactic acid moiety), —OC(═O)CH2OCH2CH2— (inverse dioxanone acid moiety), —OC(═O)CH2CH2CH2CH2CH2— (inverse caprolactone acid moiety), —OC(═O)(CH2)y—, or —OC(═O)CH2(OCH2CH2)z—;Y, Y1, and Y2 are independently at each occurrence —CH2C(═O)O— (glycolic acid moiety), —CH(CH3)C(═O)O— (lactic acid moiety), —CH2CH2OCH2C(═O)O— (dioxanone moiety), —CH2CH2CH2CH2CH2C(═O)O— (caprolactone moiety), —(CH2)yC(═O)O—, or —(CH2CH2O)zCH2C(═O)O—;each y and z is independently an integer from about 2 to about 24;each a, b, c, and d is independently an integer from about 1 to about 6. |
