Composition for nasal administration and method for preparing same

摘要

The invention provides a powdered composition for nasal administration, comprising a physiologically active peptide and cellulose acetate as the base, and having excellent nasal absorption for physiologically active peptides.

主权项

1. A powdered composition for nasal administration comprising a physiologically active peptide and cellulose acetate as a base, wherein the composition is obtained by 1) mixing the physiologically active peptide, cellulose acetate and at least 20 wt % of water with respect to the cellulose acetate, and 2) drying the mixture,
wherein the physiologically active peptide is human glucagon-like peptide-1, human parathyroid hormone (hPTH), hPTH (1-34), human motilin, a human motilin derivative consisting of the amino acid sequence of SEQ ID NO: 1, human ghrelin, human atrial natriuretic peptide, brain natriuretic peptide (BNP) or C-type natriurectic peptide (CNP).