The present application relates to immunogenic compositions comprising staphylococcal PNAG which is less than 40% N-acetylated and is conjugated to a carrier protein by a linker bonded to an amine group on PNAG to form a PNAG conjugate. Vaccines, methods of treatment using and processes to make an immunogenic composition comprising PNAG and Type 5 and/or 8 capsular polysaccharides are also described.
申请公布号
CA2647450(C)
申请公布日期
2014.08.12
申请号
CA20072647450
申请日期
2007.03.29
申请人
GLAXOSMITHKLINE BIOLOGICALS S.A.;THE BRIGHAM & WOMEN'S HOSPITAL, INC.
发明人
BIEMANS, RALPH LEON;DENOEL, PHILIPPE;DUVIVIER, PIERRE;MAIRA-LITRAN, TOMAS;POOLMAN, JAN