Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide,申请号US201213624241-传众专利搜索

发明名称	Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
摘要	The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.
申请公布号	US8802868(B2)	申请公布日期	2014.08.12
申请号	US201213624241	申请日期	2012.09.21
申请人	Vertex Pharmaceuticals Incorporated	发明人	Keshavarz-Shokri Ali;Zhang Beili;Alcacio Tim Edward;Lee Elaine Chungmin;Zhang Yuegang;Krawiec Mariusz
分类号	C07D405/12;A61K31/36	主分类号	C07D405/12
代理机构	Honigman Miller Schwartz and Cohn LLP	代理人	Honigman Miller Schwartz and Cohn LLP ;Berven Heidi M.;O'Brien Jonathan P.
主权项	1. (R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide crystalline Form A characterized by one or more peaks at 19.3 to 19.7 degrees, 21.5 to 21.9 degrees, 16.9 to 17.3, and 20.2 to 20.6 degrees in an X-ray powder diffraction obtained using Cu K alpha radiation.
地址	Boston MA US