Use of the spin crossover complex [m^x+(L_Y)H_W]AN)_Zas a magnetic resonance imaging contrast agent

摘要

A method for magnetic resonance imaging of a human or animal body includes providing a spin crossover complex having the general formula [Mx+(Ly)Hw]AN)z wherein,
MX+ is a positively charged metal ion,Ly is a heteroaromatic ligand containing at least one nitrogen atom in its ring system,AN is a negatively charged inorganic anion,w is 0, 1 or 2,x is 2 or 3,y is 2 or 3, andz is 2, 3 or 4.;The spin crossover complex is applied as a contrast agent in a magnetic resonance imaging of the human or animal body.

主权项

1. A method for magnetic resonance imaging of a human or animal body, the method comprising:
introducing into the human or animal body a contrast agent comprising a spin crossover complex of formula
[M(Ly)Hw](AN)z wherein, M is Fe2+,Fe3+, or Co2+, L is 4′-(4′″-pyridyl)-1,2′:6′1″-bispyrazolylpyridine, AN is a negatively charged inorganic anion, w is 0, 1, or 2, y is 2 or 3, and z is 2, 3, or 4; and conducting magnetic resonance imaging on the human or animal body.