Neural stimulation modulation based on monitored cardiovascular parameter

摘要

A system example may include a vagus nerve stimulator, a physiological parameter monitor and a controller. The stimulator may be configured to deliver vagus nerve stimulation in a recurring succession of stimulation cycles, where the vagus nerve stimulation is provided for a portion of each cycle and not provided for another portion each stimulation cycle. The monitor may be configured to monitor a physiological parameter within the portion of each cycle when the stimulation is generated and within another portion of each cycle when the stimulation is not generated. The controller may be configured to determine a change in the sensed physiological parameter where the change reflects a difference in the sensed physiological parameter between the portions of a stimulation cycle, compare the detected change to a target change to provide a comparison result, and adjust the vagus nerve stimulation based on the comparison result.

主权项

1. A method, comprising:
delivering vagus nerve stimulation in a recurring succession of stimulation cycles, wherein the vagus nerve stimulation is provided for a portion of each cycle and not provided for another portion each stimulation cycle; sensing a physiological parameter within the portion of each cycle when the stimulation is generated and within another portion of each cycle when the stimulation is not generated; determining a change in the sensed physiological parameter, wherein the change reflects a difference in the sensed physiological parameter between the portions of a stimulation cycle; comparing the change to a target change to provide a comparison result; and adjusting the vagus nerve stimulation based on the comparison result.