| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to novel in vivo visualising agents of formulaI, where Rstands for Calkyl, Cfluorinealkyl; Rstands for H, OH, halogeno, Calkyl, Calkoxy, Cfluoroalkyl, Cfluoroalkoxy; Rand Rindependently stand for Calkyl, C-Caralkyl or Rand Rtogether with nitrogen atom, to which they are bound, form nitrogen-containing Caliphatic ring; Ystands for CH; Ystands for CH, CH-CH, CH(CH)-CHor CH-CH-CH; and where formula I, as it is determined, contains atom, which represents radioactive isotope, suitable for visualisation in vivo, selected fromC,F,Br,I,I andI. Claimed compounds bind with PBR with high affinity, have good absorption in brain after introduction. Described is method of obtaining in vivo visualising agent and set for claimed method realisation.EFFECT: radio-pharmaceutical composition, which contains in vivo visualising agent, is described.21 cl, 13 dwg, 18 ex |
