| 摘要 |
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I):;;including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. |
| 主权项 |
1. A compound having the following Formula (I):or a stereoisomer or pharmaceutically acceptable salt thereof,
wherein:
X is —O— or —NZ3— or —CHZ3—;W is —CHZ2—;Z1, Z2 and Z3 are each, independently, hydrogen or C1-3alkyl, or wherein Z1 and Z2 or Z1 and Z3, taken together, form -L- wherein L is —C(Ra)2—, —C(Ra)2C(Ra)2—, —C(Ra)2C(Ra)2C(Ra)2—, or —C(Ra)2C(Ra)2C(Ra)2C(Ra)2—, wherein at least one of Z1 and Z2 or Z1 and Z3, taken together, form -L-;Z4 is a bond, —CH2—, or —CH2CH2—;Y1 and Y2 are each, independently, hydrogen, C1-3alkyl or C1-3haloalkyl;R1 is phenyl substituted with one to three halogens; andeach Ra is, independently, hydrogen, halo, hydroxyl or C1-4alkyl. |
