METHODS OF MODULATING HVEM, BTLA AND CD160 CIS COMPLEX RESPONSE OR SIGNALING ACTIVITY WITH SOLUBLE LIGHT POLYPEPTIDE SEQUENCES

摘要

The invention provides HVEM cis complexes which include, for example, HVEM/BTLA, HVEM/CD160 and HVEM/gD cis complexes. The invention provides ligands and agents that bind to HVEM cis complexes, such as antibodies. The invention further provides methods of use of the HVEM cis complexes, and the ligands and agents (e.g., LIGHT polypeptide sequence) that bind to the HVEM cis complexes.

主权项

1. A method of modulating a HVEM, BTLA or CD160 response or signaling activity, comprising contacting a cis complex comprising a herpes virus entry mediator (HVEM) polypeptide binding to B- and T-lymphocyte attenuator (BTLA) polypeptide, or a cis complex comprising a herpes virus entry mediator (HVEM) polypeptide binding CD160 polypeptide with a soluble LIGHT polypeptide sequence that binds to the cis complex, thereby modulating a HVEM, BTLA or CD160 response or signaling activity.